Madonna was forced to cancel another show on her Madame X world tour, as she continues to fight and ongoing injury.
"Sorry I had to cancel tonight", she told her 14.7 million followers Sunday night.
It is the eighth time she has cancelled gigs on her world tour.
In a video posted on social media last week, she was shown kneeling while rehearsing for an earlier show in Lisbon.
Madonna cancelled the latest stop on her Madame X Tour on Sunday so she could rest.
The Madame X concert scheduled for tonight, January 19 at the Lisbon at The Lisbon Coliseum is cancelled. She recently posted snaps online showing her taking an ice bath to soothe her pain.
Cancelling shows over in the United States in Boston, Madonna said she was in "overwhelming pain" from multiple injuries.
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The mother-of-six has not disclosed the nature of her injury. "See you on Tuesday fingers crossed", she wrote on Instagram.
Madonna is due to perform at the same venue on Tuesday, Wednesday and Thursday before heading to the London Palladium.
Many had flown in from around the world to see their "queen" grace the intimate venue, just a few miles from her new Portuguese home.
After all, fans are fully aware that this is an all-out performer, battling against injury, who offers no compromise on stage.
An email was sent to ticketholders at 7.45pm ahead of her expected appearance on stage at 8.30pm.
US singer Madonna performs during the Rebel Heart World Tour in Macau, China, Saturday, Feb. 20, 2016.
The pop star later took to Instagram, and shared her apologies with fans.