The third test at St George's Park is followed by the last at the Wanderers in Johannesburg from Jan 24-28.
The country's oldest Test venue, it has seen the tourists prevail in five of the nine bilateral contests on record, with three draws and just a lone South African triumph.
It also played host to South Africa's first rugby worldwide, also against England, two years later.
South Africa will look for more consistent hostility from Rabada, while Anrich Nortje, the fastest bowler on either side, will be keen to impress on his first Test appearance in his home town.
Arguably the team's worst loss, though, was at St George's Park last February when they were beaten by Sri Lanka inside three days? after Du Plessis won the toss.
South Africa were then dismissed for 134 the second time around, with legendary English quickie Frank "Typhoon" Tyson claiming 6/40.
Keshav Maharaj bowled tidily for South Africa in the 1st innings at Newlands but numbers of two for 160 into the 2nd innings revived memories of an unhealthy trip of India to the end of this past year whenever their six wickets are priced at 85.66 operates each.
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Dom Bess, maybe not the main initial touring team, performed a sufficient job for England, bowling financially but getting only 1 wicket in each innings.
First-choice spinner Jack Leach has yet to appear on tour after falling ill soon after arrival.
Leach is the third player to be ruled out of a tour that has been disrupted by frequent medical bulletins, joining Rory Burns (ankle) and James Anderson (rib) on the sidelines.
Where can I get tickets for South Africa vs England? .
- a complete of 68,662 spectators created an exciting environment at Newlands but anecdotal proof implies that around 40,000 of these had been supporting England.
Nevertheless some 5,500 tickets were sold in advance for the first day and it is likely most of those were bought on behalf of England fans, with locals generally preferring to turn up on the day.