They have been left short after the departures of Romelu Lukaku and Alexis Sanchez in the summer window.
Mandzukic has proved his worth over the years.
Reports have stated that the two clubs reached an agreement on a fee of £10m earlier this season, although others suggest that United may have to pay between £13m and £15m altogether.
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Similarly, Corriere dello Sport have mentioned that the Old Lady's sporting director has traveled to London to resolve the future of Mandzukic and inquire about signing Paul Pogba from the Red Devils.
United are desperate for depth in attack with Marcus Rashford and Anthony Martial the only recognised senior strikers.
However, United could certainly do with another top class option through the middle and Mandzukic would be a decent short-term fix as he has bags of experienced having played for the likes of Bayern Munich, Atletico Madrid and Juventus during an illustrious career.
Manchester United could get their wish of signing a prolific goal scorer in January realized after the Croatian striker declared his interest in joining the Red Devils.