The report said numerous injuries happened as people fled in panic.
A night-time natural disaster in northwestern Iran on Friday killed five people and injured 120, according to early reports on state television. The area is some 250 miles northwest of the capital, Tehran.
Last year, a quake that struck near the Iran-Iraq border in November killed at least 361 people.
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Provincial governor, Mohammad-Reza Pourmohammadi, told Tasnim that at least 400 houses had been damaged or fully destroyed.
Emergency services have been distributing survival kits, cooking equipment, blankets and tents, according to AFP news agency.
Around 50 aftershocks have also been felt in the region, up to a magnitude of 4.8, and led to people sleeping outside in the cold due to fears of buildings collapsing. Let me tell you, a 5 magnitude natural disaster can cause a lot of damage, although no casualties have occurred here during this time.
A magnitude-2.3 quake rattled northeast of San Simeon on Thursday morning, according to the U.S. Geological Survey. In 2003, a magnitude 6.6 quake in Kerman province killed 31,000 people and flattened the ancient city of Bam.