Noteboom sustained a torn ACL and MCL in his right knee in the first quarter against the 49ers and will miss the rest of the season.
Now both are piling up for the Rams, who have lost three consecutive games for the first time under McVay.
McVay said the Rams would fill the starting role in-house with either Demby or David Edwards, a rookie lineman from Wisconsin, but they could add a veteran for depth. "People seem to think that things aren't going that well, but I think our guys are continuing to believe".
"It presents an opportunity for us to be what we say (we are)", McVay said.
The Rams will have to regroup without cornerback Aqib Talib and left guard Joe Noteboom, who will be placed on injured reserve. Subscribe to the 49ers Report on YouTube for the latest rumors, news, mailbags & much more all season long!
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The Rams are placing Aqib Talib on the injured reserve, according to multiple reports, leaving the defense without one of its key players.
Whether someone like Jamil Demby steps up or Los Angeles simply looks to make a trade before the deadline, it's going to be hard to replace Noteboom after his latest injury. Rams quarterback, Jared Goff, was held to a career-low 78 yards passing on a less than efficient 3.3 yards per attempt.
"We're killing ourselves with early-down efficiency", McVay said.
Only the New England Patriots are allowing fewer yards per game than the 49ers. For the 49ers' defense to put up numbers against the pass that look like something out of the 1980s is a great credit to the job Saleh is doing, and the biggest reason they're 5-0.
After holding the Browns to three points last week, the 49ers defense picked up right where it left off, limiting the Rams to seven points on the afternoon.