It is expected to perform the tasks of astronauts like going on a spacewalk, especially on missions which are not suitable for the survival of human beings.
The docking of Soyuz MS-14 spacecraft with the Russian Fedor, short for Final Experimental Demonstration Object Research, robot took place several minutes ahead of the schedule, it said.
After the successful docking at the second attempt, a NASA TV commentator praised the vessel's "flawless approach to the ISS". The robot was perceived saying in the course of the launch replicating the phrase utilized by the foremost man in space Yuri Gagarin.
Usually, Soyuz rockets are manned for these missions, but in order to test a new emergency rescue system, it remained unmanned this time around.
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A previous docking attempt had failed on Saturday, due to a faulty component within one of the ISS's automatic docking ports.
Robots like Fedor will eventually carry out unsafe operations such as spacewalks, according to the Russian space agency.
Fedor is not the first robot to go into space. NASA sent humanoid robot Robonaut 2 to space in 2011 to work in hazardous environments. In the captain's seat of the capsule, which is created to carry human passengers, sat Skybot F-850, a humanoid robot built by Russia's Rocsomos space agency.
It was flown back to Earth in 2018 after experiencing technical problems. Developed with Toyota, it was in a position to maintain conversations - albeit exclusively in Japanese.
The International Space Station has been orbiting Earth at about 28,000 kilometers per hour (17,000 miles per hour) since 1998.