Curry and Underhill, who have both been hard hit by injury, bring a dynamic dimension to the flanks, where Jones still seems some way from settling on his preferred combination.
After a win and defeat against Wales in back-to-back fixtures, Jones has revealed a stronger hand after his somewhat experimental starting XV against Wales in Cardiff last weekend were slayed; with Owen Farrell and George Ford both in the same line-up for the first time in nearly a year. Manu Tuilagi (outside center ) and Jonny May (left wing) come in the backline, while Ben Youngs begins his very first warm-up game at scrum-half.
The only downside for the hosts was the short-lived appearance of prop Mako Vunipola, who lasted only a few minutes as a replacement on his return from a serious hamstring injury.
Byrne and replacement Jack Carty can now make their case for World Cup selection at Twickenham, with head coach Schmidt assessing all his fly-half options.
Ireland have named a strong side for the Twickenham Test, with experienced Cian Healy and Tadhg Furlong joining captain Best in the front row.
Bundee Aki and Garry Ringrose start in the centres with wingers Jordan Larmour and Jacob Stockdale starting either side of fullback Rob Kearney.
The Twickenham fans were enjoying it and they were in full voice when Manu Tuilagi got the third off the back of an impressive scrum - albeit via loose Irish defending.
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All Jones's selections came off, with Owen Farrell converting six of the tries and landing an early penalty from inside center.
Elliot Daly continues at full-back, with Ben Youngs partnering club-mate Ford in the half-backs. Joe Marler, 2. Jamie George, 3.
The one-way traffic continued after the break, however, as locks Maro Itoje and George Kruis both powered over the line.
Both coaches emptied their benches and as the game became somewhat chaotic, Bundee Aki skinned Daly for Ireland's second try, only for replacement hooker Luke Cowan-Dickie to cash in on a awful Irish lineout to take the score into record margins. Mako Vunipola, 18. Dan Cole, 19.
I hope the only reason they're going back to starting the two of them together is because Henry Slade is still injured and Jonathan Joseph and Piers Francis have started both of the opening two warm-up games against Wales.
"We can be a lot better and we have to be a lot better", captain Rory Best told Sky Sport. Jean Klyne, 6. Peter O'Mahony, 7. Devin Toner, 20. Tadhg Beirne, 21.