The drugs will now be used to treat all patients with the disease in DR Congo, according to health officials.
Therefore it can no longer be called an incurable disease.
The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute's Department of Science Education.
The epidemic has been declared a public health emergency of worldwide concern by the World Health Organization.
It was the first-ever multi-drug trial for an Ebola treatment. Researchers administered one of four drugs to the 681 patients who had participated in the study as of Friday.
An global World Health Organisation-coordinated team consisting of the Institut National de Recherche Biomedicale, the Democratic Republic of Congo Ministry of Health, and three humanitarian organisations began conducting trials in November 2018 and aimed to compare the effectiveness of new therapies on 725 patients. Across all levels of infection, patients who received REGN-EB3 had a mortality rate of 29 percent, while those treated with mAb-114 had a mortality rate of 34 percent.
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The average fatality rate for people with the disease is around 50 per cent.
A clinical trial evaluating 4 experimental therapeutics for Ebola virus disease has been halted after an independent data and safety monitoring board determined 2 of the therapies were linked with better rates of survival.
"This recommendation was based on the fact that an early stopping criterion in the protocol had been met by one of the products, REGN-EB3".
"This underscores the importance of doing randomized, controlled trials. You can get ethically sound and scientifically sound information rapidly", he said.
Ebola spreads among humans through close contact with the blood, body fluids, secretions or organs of an infected person.
"The public should not panic if they see health workers in protective gear, ambulances or other Ebola-related activities as these are part of the simulation only", he added. Tedros Ghebreyesus, the WHO director general, said last month that more than 200 health professionals had been attacked since January and several had been killed. "A long-running outbreak like this takes its bad toll on the affected communities, and it's a sign of just how challenging it has been to control this epidemic that there have been sufficient number of patients treated for telling us more about these four drugs' efficacy", said director of the Wellcome Trust, Dr. Jeremy Farrar.
Mike Ryan, head of the WHO's emergencies program, said the trial's positive findings were encouraging but would not be enough on their own to bring the epidemic to an end.