But 23-times Grand Slam singles champion Williams holds a convincing 19-2 lead in their head-to-head battles, with the 2012 Olympics, 2013 French Open and 2015 Australian Open among her final victories over the Russian.
Top seed Osaka's bid to defend her title at Flushing Meadows begins against Anna Blinkova, while Kiki Bertens is a potential quarterfinal opponent.
Even the slam name victor features a record inside their WTA Tour clashes, and the lop-sided number will probably perform very little to soften the pleasure round what's going to be the match of this round soon.
Djokovic, bidding for his second straight Grand Slam title following his success at Wimbledon earlier this year, will be aiming to defend the title he won 12 months ago at Flushing Meadows when he beat Juan Martin del Potro in the final.
Djokovic is the top seed in the men's draw.
Djokovic is in the same half of the draw as five-time champion Roger Federer, who will play a qualifier in the first round, and is projected to meet the unsafe Russian Daniil Medvedev in the quarter-final.
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The inversion of the yield curve also affected the British debt market, which also further increased the pressure on its stocks. EURUSD slipped from 1.1200 to 1.1150 over the previous two days, while the stock markets have experienced a rather bumpy road.
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In the second quarter, Xiaomi's smartphone shipment in western Europe soared 53.2 percent, the fastest growth among major brands. This was also helped by aggressive promotions from the top vendors to take advantage of a weakened Huawei.
Ramos officiated as the chair umpire in the last year's US Open women's singles final between Serena and Japanese Naomi Osaka, CNN reported. The Czech Republic's Karolina Pliskova is No. 3, followed by Romania's Simona Halep and Ukraine's Elina Svitolina.
Williams, seeking a record-equalling 24th Grand Slam title, has been handed the No 8 seeding by the US Tennis Association.
Federer has a less accomplished quarter of the draw with no other Grand Slam winners.
If Roger Federer and Rafael Nadal are to meet for the first time at a U.S. Open this year, it will have to be in the final.
Nadal faces a potential first-round test against John Millman, the Australian who knocked Federer out in the fourth round at Flushing Meadows past year.