Knox has returned to Italy for the first time since she was convicted and imprisoned, but ultimately acquitted, for the murder and sexual assault of her British roommate Meredith Kercher in the university town of Perugia in 2007.
CNN reports Knox, 31, landed in Milan on Thursday is headed to the northern city of Modena, where on Saturday she will appear as a guest speaker on a panel discussion on wrongful convictions organized by the Innocence Project.
Knox was an American student studying overseas in Perugia in 2007 when she was accused of brutally murdering roommate Meredith Kercher, 21, who was found half-naked with her throat cut in her bedroom.
The killing of Knox's roommate in the university town of Perugia, 21-year-old Meredith Kercher, on November 1, 2007 attracted global attention, especially after suspicion fell on the photogenic Knox, and her boyfriend, Raffaele Sollecito.
Rudy Guede, another suspect who was later convicted of Kercher's murder, is serving a 16-year sentence, the Associated Press reported. After multiple trials and overturned rulings, Knox spent four years in prison for slander and having unjustly accusted a Congolese bar owner of the crime.
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Before traveling to Italy, she published an essay titled "Your Content, My Life", about the decision to accept the panel invitation from the Italy Innocence Project.
"While on trial for a murder I didn't commit, my prosecutor painted me as a sex-crazed femme fatale, and the media profited for years by sensationalizing an already sensational and utterly unjustified story", she wrote.
Amanda Knox returned to Italy to speak about wrongful convictions for the first time since being acquitted of murdering her roommate. "Amanda has been definitively acquitted in court, but in the popular imagination she is still guilty, because she has been the victim of a barbaric media trial".
"And as this homecoming looms (or is it a "deployment" or "madness" - no word seems to fit), a different sort of surreal moment is at the forefront of my mind", Knox wrote Wednesday about her return to Italy. "Here we go. Wish us, 'Buon viaggio!'" she wrote.