Ms Knox's October 2011 acquittal - following a lower court conviction that brought a 26-year prison sentence - was one step in the long legal process that saw a series of different rulings before she and Mr Sollecito were definitively acquitted in 2015 by Italy's highest court.
Knox, who announced her participation in the Italy Innocence Project last month, gained global attention in 2007 after suspicion fell on her and then-boyfriend Raffaele Sollecito for the murder of her roommate Meredith Kercher.
Amanda Knox returned to Italy to speak about wrongful convictions for the first time since being acquitted of murdering her roommate.
The Seattle native was 20-years-old at the time of the murder of Briton Meredith Kercher, a fellow exchange student whose half-naked body was found on November 2, 2007, in a bedroom of the apartment she and Knox shared in the central city of Perugia.
In January, the European Court of Human Rights ordered Italy to pay Ms Knox €18,400 in financial damages for failures to provide adequate legal and translation assistance during her early questioning by police.
Rudy Guede, an Ivory Coast-born drifter, and small-time drug dealer was eventually convicted of the murder and is serving a 16-year sentence in an Italian prison.
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Italy's top court overturned the acquittal in 2013 and, upon retrial (at which Amanda wasn't physically present), upheld the murder conviction. "Wish us, 'Buon viaggio!'"
"I've chosen not to do interviews in the lead-up to Italy, in the hopes that what I will say in Modena will speak for itself", Knox tweeted Wednesday.
Feigning fear, she captioned the shot: "3 Days till I return to Italy for the first time since leaving prison". The case quickly became an global spectacle, with audiences the world over feverishly debating the subject of her innocence.
"I'm about to return to Italy for the first time since I was released from prison and fled the country in a high-speed chase, paparazzi literally ramming the back of my stepdad's rental vehicle", she wrote on Gen by Medium. In her free time, she enjoys watching (and talking!) about television and fostering dogs through a local rescue.
She first began to think of her life as "other people's content" with the release of Netflix's "Amanda Knox" documentary in 2016, when she caught sight of a billboard advertising her story with the words "monster" and "victim" on the billboards, she explained.
Mr Maresca said of her decision to return to Italy: "I think it is inappropriate and uncalled for".