Just 19 days before the United Kingdom is due to leave the European Union on March 29, May's is scrambling - so far unsuccessfully - to secure last-minute changes to an European Union exit agreement before a vote on Tuesday on whether to approve the deal.
With opposition parties and scores of Conservatives opposing it for various reasons, MPs vote by 432 to 202 against the deal - the worst defeat for a government in modern British political history.
Among the signatories of the letter were major local and multinational employers including Bombardier, Coca-Cola, Danske Bank, Norbrook Laboratories, Queen's University Belfast, the Viridian Group and Royal Bank of Scotland's Ulster Bank unit.
If Mrs May's deal is rejected, she then faces a likely defeat on a second vote to prevent a no-deal exit on March 29 and a third vote to extend the Article 50 exit process, possibly until the end of June.
Hunt also suggested Brexit would have to be delayed if the deal is passed and the Labor party's shadow Brexit secretary Sir Keir Starmer said delaying the withdrawal for three months is "probably doable".
Instead, they said the Prime Minister should table a motion outlining the kind of Brexit deal Tory MPs would accept in a bid to maintain party unity and put pressure on Brussels, according to the report.
He said: 'The government losing this week makes probable either a no-deal by accident, as we have to leave under the law, or we get no Brexit.
There has been speculation that the beleaguered prime minister may be forced to resign.
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The backstop would keep the whole United Kingdom in a customs union with the EU in order to keep the land border between the UK's Northern Ireland and the Republic of Ireland free-flowing. She has already said she will stand down before the next election, in 2022, but there is already pressure from inside her own Conservative Party for her to quit within the next few weeks if she can not deliver Brexit on time.
Attorney General Geoffrey Cox told the Mail on Sunday that any arbitration mechanism secured for the Irish border backstop could be triggered on "the very first day".
May's spokesperson said a "meaningful" parliamentary vote on her deal would go ahead on Tuesday, even though talks with the European Union are deadlocked, and the motion would be published later on Monday.
Earlier, Tanáiste and Minister for Foreign Affairs Simon Coveney said Brexit negotiations are ongoing, and that he understands Mrs May is to travel to Strasbourg to seek to finalise an agreement.
"It is inevitable this unchanged withdrawal agreement will be voted down again", two senior Brexit-supporting MPs, Conservative Steve Baker and Nigel Dodds of the Democratic Unionist Party (DUP), warned on Sunday.
"Business is holding its breath ahead of the votes in parliament this week, knowing that if Brexit has taught us anything, it is to expect the unexpected", said James Stewart, head of Brexit at KPMG UK.
The Labor Department said the USA economy created just 20,000 jobs last month, a fraction of what was expected. Following that crushing defeat she agreed to renegotiate certain unpopular aspects of the agreement and hold another vote this Tuesday.
The EU's chief Brexit negotiator Michel Barnier told AFP on Monday that negotiations to break a deadlock on a deal to leave the bloc are now between May and members of her parliament. Prime Minister Theresa May and European Union officials agreed to the agreement in December, but United Kingdom lawmakers voted 432-202 in January to reject it.