The National Railway Authority said a train collided with a concrete buffer stop at the central Ramses Station.
A speeding railcar crashed into a barrier at Cairo's main train station, causing its fuel tank to explode and triggering a huge fire that left at least 25 people dead on Wednesday, officials said.
Security sources said there was no indication that the crash was deliberate.
Local newspaper Al-Ahram reported the train crashed and the fuel tank exploded, but details of the incident have not been confirmed. And I don't know what happened to him, " eyewitness Ibrahim Hussein told Reuters.
Footage also showed fire engulfing the train and a nearby platform and people rushing to help the injured.
"I was standing on the platform and I saw the train speed into the barrier", another witness Mina Ghaly said.
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"I saw at least nine corpses lying on the ground, charred", he added.
Prime Minister Mostafa Madbouli, Minister of Social Solidarity Ghada Wali, and Minister of Transportation Hesham Arafat arrived at the scene.
The country's deadliest rail accident occurred near Cairo in 2002, when a fire ripped through an overcrowded passenger train, killing more than 370 people.
Egypt's railway infrastructure has always been neglected by successive governments and previous train accidents have been blamed on a lack of investment and poor management of the railway network.
People gather outside Ramsis train station in Cairo, Egypt, Wednesday, Feb. 27, 2019. "They told us they got millions of dollars' worth of new locomotives and trains, and people are still dying because of train accidents".