An error from the goalkeeper - he fumbled an 83rd-minute shot from Heung-Min Son - gifted Tottenham Hotspur a 1-0 win this afternoon.
For all the hosts dominance of possession, Martin Dubravka was only forced into one serious save before the break when former Newcastle midfielder Moussa Sissoko turned a well-worked corner towards goal.
Son started against Newcastle and played the full 90 minutes again.
He was left in acres of space by a failed Newcastle offside trap and was found perfectly by Erik Lamela's cross, but the Brazilian planted a free header from seven yards out wide of the target.
Fabian Schar came to his side's rescue midway through the second period, his goal-line clearance preventing Christian Eriksen's flick from breaking the deadlock.
The deadlock was eventually broken with eight minutes remaining as Son evaded two defenders before firing home from range although Dubravka should have done better.
Son's winning goal against Newcastle took his Premier League tally for the season to 10, including two since he returned from worldwide duty with South Korea at the Asian Cup.
"They were pushing really hard, and we concede a goal we could have avoided".
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Pochettino confirmed Son was disappointed after failing to lead South Korea to more glory, having done so last summer in the Asian Games.
Spurs go into the game without injured trio, Dele Alli, Harry Kane and Ben Davies, although it has been suggested that Kane is ahead of schedule with his recovery.
They are now above Manchester City in second, four points behind leaders Liverpool, with both teams not in action until Sunday and Monday respectively.
Tottenham beat the Magpies in their first game of the season to see themselves off to the flawless start.
It's perhaps one last chance for Janssen to turn his Spurs career round, and the development could make for frustrating news for another first-teamer.
Mauricio Pochettino has made three changes from the side that beat Watford in midweek with Kieran Trippier coming in for Serge Aurier at right-back.
"We [Tottenham] are still there, we're going for the Premier League title, and we can stop them".
But the Netherlands global is now set to be added to the club's 25-man Premier League squad list.