The American upset 11th seed Aryna Sabalenka 6-3, 6-2 in 65 minutes to set-up a fourth-round meeting with either eighth seeded Czech Petra Kvitova or Switzerland's Belinda Bencic, and she has her sights set high.
"I want to win this tournament", Anisimova said, tapping her right index finger on a table for emphasis at her post-match news conference.
Anisimova will meet either No.8 seed Petra Kvitova, who she beat at Indian Wells a year ago, or Switzerland's Belinda Bencic on Sunday for a place in the quarter-finals.
All of 17, never the victor of a Grand Slam match until this week, Amanda Anisimova is making quite a first impression at the Australian Open.
Roger Federer's 6-2 7-5 6-2 victory over Taylor Fritz was the Swiss marvel's 17th in a row at Melbourne Park and propelled the 37-year-old two-time defending champion into the fourth round for the 17th time in his past 18 attempts.
"Her story is phenomenal", Sharapova said.
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Birthday girl Angelique Kerber humiliated Australian wildcard Kimberly Birrell 6-1 6-0 to storm into the fourth round of the Australian Open on Friday and complete a late-night horror show for the locals at Rod Laver Arena.
Anisimova took charge right away, earning a break point in the opening game of the match after a successful challenge of a Sabalenka backhand and she converted when she blasted her own backhand past the Belarussian.
The Belarusian was a darkhorse to not only win the title, but was one of 11 women in the running to leave the Australian Open with the No.1 ranking at the start of the tournament. "I was just playing really well and she was playing really well, too", said Anisimova. I was going to be playing on a big court. I'm really feeling good out here.
Also Friday, No. 5 Sloane Stephens survived two tough tiebreak sets to beat No. 31 Petra Martic 7-6, 7-6.
The crowd sang "Happy Birthday" as she left the court. He overcame two match points - opponent Fernando Verdasco double-faulted one of them away - and erased a two-set hole to win 4-6, 3-6, 6-1, 7-6 (8), 6-3 in a contest that lasted more than 4 hours and ended just before 1 a.m.