Osaka will face world No. 86 Magda Linette, of Poland, in the first round of the Australian Open.
Wozniacki also has a question mark over her fitness after the 28-year-old Dane revealed her battle with rheumatoid arthritis last October, but has since claimed that she has learnt to live with it.
The 31-year-old went into a bewildering slump in mid-2016 that only ended when he won Wimbledon last year, before he went on to claim his third US Open crown and move to 14 grand slam titles, three behind Rafa Nadal. Williams reached the Wimbledon and US Open finals after her return past year but lost both, leaving her one short of Australian Margaret Court's tally of major singles titles.
Simona Halep of Romania hits her racquet against the floor as she looses a set against Kaia Kanepi of Estonia (not seen) at the US Open in Louis Armstrong Stadium in New York, United States on August 27, 2018.
As far as the final match is concerned, in-form Angelique Kerber of Germany could be Williams' opponent.
Regarding the controversial final against Osaka at Flushing Meadows - when she raged against umpire Carlos Ramos who imposed three code violations, the final one resulting in the loss of a game - Williams said she had put it put behind her and meant to "move on to bigger and better things".
Flu season has returned
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Rare penny from school lunch change up for auction
All cents were supported to be made with zinc-coated steel in order to conserve copper for the war effort. These few planchets went unnoticed when the bins were refilled with zinc-coated steel planchets in 1943.
California man steals $10K lottery ticket; ends up worth $10M
But when he attempted to collect his winnings the following morning, he was told his ticket wasn't a victor and had been altered. The alleged forgery even had the wrong winning amount listed: $10,000 instead of $10 million.
She warmed up for Melbourne by making the semi-finals of the Brisbane International last week, where she blamed a poor attitude for losing to Lesia Tsurenko.
Amid unsavoury scenes, Osaka went on to win her maiden grand slam title.
"I have no reason to believe that Sabalenka will not win more than one Grand Slam. Why?"
"I feel like if there's one thing I should be able to do it's draw a tennis ball", the Olympic gold medalist, 37, explained.
Serena received a code violation for coaching, a penalty point for racquet abuse and a game penalty for calling the umpire a "liar" and a "thief" during the US Open final. "Don't be surprised if you hear about a part-time job I've picked up at a local nail salon", she wrote.
Osaka, who turned pro at just 14-years-old, is the fourth seed at the 2019 Australian Open - which begins January 14 in Melbourne. I will have a few more years of tennis and then I want to improve in other ways.