On Saturday, in a major hint she was preparing her presidential bid, Warren dropped the MA reference from her campaign Twitter handle, changing it from @elizabethforma to a more nationalized @ewarren.
But, Warren said, regular people in American faced more hard challenges in 2018. She is unlikely to seek the assistance of a billionaire-funded super PAC, according to a source familiar with Warren's thinking, because she believes grassroots support should be a defining factor in the coming primary. She is hoping her reputation as a populist fighter can help her navigate a Democratic field that could include almost two dozen candidates.
Warren is expected to base her campaign headquarters in Boston, with an operation likely to be led by her longtime aide Dan Geldon. Bernie Sanders, a Vermont independent who is eyeing another presidential run harnessing the same populist rhetoric.
"The country will realize that after trying every kind of guy, it's time to let a woman clean up the mess", she said. Her rivals could include former vice-president Joe Biden and Beto O'Rourke, who lost the Senate race in Texas in 2018.
Ms Warren, a former Harvard Law School professor, campaigned in 2016 with Democratic presidential candidate Hillary Clinton.
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It also suggested she had become too much of a "divisive figure", an apparent reference to the heavily publicized DNA test. It was her upbringing, and family lore, that caused her to say for several years that she was Native American - a claim that has come under relentless attack from Republican opponents, prompting the DNA test that triggered a Democratic backlash.
Formerly a professor of law at Harvard, the MA senator is considered to be on the liberal wing of the Democrat Party.
Cherokee Nation Secretary of State Chuck Hoskin Jr. was among the most outspoken critics and said Warren had undermined "tribal interests".
Senator Elizabeth Warren (D-Mass.) has always been rumored to be a potential 2020 presidential candidate.
But almost two months after Ms. Warren released the test results and drew hostile reactions from prominent tribal leaders, the lingering cloud over her likely presidential campaign has only darkened. "Others can be more of a loner, or willing to charge into battle first before having a fully baked plan".