In terms of temperatures, highs will reach near 60° around Denver, Boulder, and Fort Collins on Wednesday and Thursday which is more than 10 degrees above normal for the third week in November.
Behind the snow, an Arctic blast sweeps into the Northeast late Wednesday, bringing record-cold wind chills in time for Thanksgiving. Temperatures will be slightly warmer Friday afternoon and winds will back off a little, making the wind chill values not almost as bad.
In the valley the main impacts will be rain and wind with a rain/snow mix at about 5,500 feet Wednesday night.
From Maine to Pennsylvania, temperatures could be lower than they've ever been on Thanksgiving, even in the years the holiday fell very late in the month.
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Thanksgiving should be dry for much, if not all, of the Midwest. In fact, the air will be SO cold on Thanksgiving Day that many USA cities from Buffalo to Boston may see new record cold maximum temperatures set for Thanksgiving Day! Temperatures reaching the teens area wide, with wind chills in the single digits by morning.
Some snow squalls will move through western NY and Pennsylvania on Wednesday.
According to the National Weather Service, a winter storm may develop overnight Saturday through most of Sunday, with south central Iowa now predicted to be in the region most likely to see significant winter precipitation.
After weeks of dry conditions under strong high pressure, a significant pattern shift will occur by Wednesday as weak to moderately strong weather system moves into the region, ' the National Weather Service in Reno, Nevada wrote on Monday. The projected high for Thanksgiving is 26 degrees. The majority of the snow will fall in the high Sierra but roads will be impacted at pass level as well.