For the first time in over seven years, Wozniacki did not lose a set during a championship run, tallying the 30th title of her career.
Argentine top seed Del Potro was far from his best and has been fighting flu or a cold for several days in the Chinese capital.
Wozniacki hit the ground running in her first service game, holding her opponent to love with a commanding use of her backhand shots down the line.
Ex-first racket of the world Caroline Wozniacki became the champion of a major tournament in China category Premier Mandatory with a prize Fund of $8,285,274.
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Wozniacki claimed the only break of the opening set and looked set to surge to the win after moving 4-1 up in the second by racing in from the baseline after Sevastova's backhand clipped the net cord.
"I could see Juan was sick today", Basilashvili said. Then after number one in the world, I wanted to win a Slam, then I wanted to lift trophies.
"I think I had a dream of that, but I don't know how realistic I really believed that was going to be". Sevastova, who has been managing a stomach muscle injury since the round of 16, broke back to give herself a chance to mount a comeback.
In another engrossing game that ebbed and flowed, del Potro saved two match points before failing to convert two break points of his own.
Caroline Wozniacki of Denmark kisses the trophy during the awarding ceremony of the women's singles event at the China Open tennis tournament in Beijing, capital of China, on October 7, 2018.