Mendy is currently unavailable for selection due to a metatarsal injury and he now faces an uncertain future with the defending Premier League champions.
City's manager denied there was any disciplinary problem with Mendy, who has a foot injury, but said: "He arrived late, and that shouldn't happen but it does sometimes".
The report suggests Mendy arrived three hours late for a scheduled treatment session on Sunday, after being seen watching Anthony Joshua's fight with Alexander Povetkin at Wembley on Saturday evening. I have spoken to him.
On his side's meeting with Brighton this weekend, Guardiola added: 'They have been together a long time, they know what they have to do. Manchester is under construction, the players arrive late.
Two of City's three wins at home this season against teams outside the big six have been by at least three goals, although their strike-rate in that category last season was only 50%, so it is far from assured that trend will continue, especially against Hughton's well-organised team.
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Guardiola has confirmed Kevin De Bruyne's recovery from a knee ligament injury is progressing on schedule, with the midfielder expected to resume training in the next week or so.
The Belgium global suffered the injury in August and was expected to be out for three months, but it is hoped he could be back in time for the Manchester derby on November 11.
Guardiola tried to lessen Mendy's transgression by claiming that traffic congestion in Manchester has been a problem for a number of his players recently.
"Everything is going well", the Manchester City manager said. "It's about my decisions, he's ready to play, of course, and he can start in any competition".
'Yeah, he's making the last steps.
"He has to make his own career".