Win or lose, this is it for Patrick, who has crafted a business empire that makes her peers jealous.
And if she does?
During a 14-year career, evenly split between IndyCar and NASCAR, it was the Indy 500 that provided most of the material for Patrick's career highlights reel and made her one of North America's most recognizable athletes.
But it was a career that was impossible to ignore.
"I just knew that I was going to be in a good auto, and that's what mattered to me", Patrick said. "There's a difference between the beginning when I signed up (to run the Indy 500 one last time) and I was hopeful that it would go well and where it is now - having tested, qualified and gotten into race mode".
"I don't really know about the female part".
"It is a career-defining race and something that changes your life forever", said Carpenter.
She did not want to be labeled a "woman" driver but did not want people to forget it either.
"She's done a great job getting up to speed, not making mistakes. She's got a great shot because she has a really good vehicle underneath her and a good team".
"The businesswoman that she is, I admire", said Penske driver Simon Pagenaud.
Patrick, 36, will have a shot to improve her career-best third-place finish (2009) in the Indy 500 - also the record for female drivers.
Patrick's latest change is no different.
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Just last month, singer Lorde got backlash after she shared a photo of a bathtub with the caption "And iiii will always love you". He also shouts out his cousin Ricky Anderson and his one-year-old son Avery, who was reportedly found unresponsive during a nap.
When Patrick came along in 2005, there were two series in US open wheel racing, the Indy Racing League and Champ Car, the result of an acrimonious split in 1996.
"I think all of my life I've kind of felt like you're only as good as your last race. They're like, 'Do you like to go really fast?' I'm like, 'No, I'm actually not a daredevil'".
It's no secret that all three of the ECR drivers and their Chevrolet-powered cars have a chance to win.
As many as 300,000 plus spectators are expected to fill the grandstands of the sprawling 2.5 mile oval for the "Greatest Spectacle in Racing" and many of those will be there to say goodbye to motorsport's most celebrated woman driver. "Danica is very involved in all of the debriefs". From the third row on the grid, she'll pilot the No. 13 GoDaddy Chevrolet for Ed Carpenter Racing for one more race before retiring from the sport.
Patrick understood early on what it would take to survive in the high-testosterone macho world of motorsport. Her business ventures will become her focus moving forward. She wants to make waffles for breakfast, enjoy Sundays like normal people and cheer for her new boyfriend and his Green Bay Packers. "She is one of the few people in the world who doesn't need a last name". "I remember previous year, you know, talking to my dad and kind of sayin" to my dad, like, you know, being emotional and being, like, "I don't really love it.' And he's like, 'I know.' He's like, 'You needed a job". So she was determined to go out her own way, which was through a "Danica Double", the 500-mile showcase races at Daytona and Indianapolis. "At the same time, the Indianapolis 500 played a big part in putting her name on the map".
"I was very fortunate", she said of her career. Not only do they provide additional information, they expand the horizons of the team's potential. "And maybe I had to prove myself a little bit more frequently". "I'm just going to drive like I normally drive; whatever happens, happens".
And once it's over?
As retirement comes racing toward her, she's never been more at ease - except for one thing. She launched her own clothing line a year ago, wrote a book on fitness and owns a vineyard in Napa Valley - all she says are part of her next journey.
She's also stepping away with no regrets, especially of her career moves. "I don't, I don't".
"There were some high points in NASCAR. It wasn't a complete failure by any means".
"So it's fitting she's ending her career here, and we hope to send her off well". "I can't wait for that", she said. "I can see Indy on the way out the way I saw it on the way in".