Mourinho told Man United's website Mourinho indicated Lukaku will also miss the Reds' final Premier League game of the season against Watford on Sunday, on the Belgian's 25th birthday, but is hopeful the striker will be fit for the Emirates FA Cup final against his former club Chelsea on May 19.
United captain Michael Carrick, who is set to retire at the end of the season and join Mourinho's coaching staff, will make his farewell appearance against Watford this weekend.
However, the 25-year-old was awarded the club's Player of the Month for April, and speaking after winning the accolade, he touched on what it felt like captaining the team at times this season.
He added: "His family asked for privacy and that is what I am going to respect".
The club had from him many great years playing football and now, when his body says "enough", the club and myself will want to keep the man.
Sanchez missed the win over Brighton last time out due to a minor knock while Jones also sat out the trip to the Amex Stadium with a muscle problem but the duo are back in contention to face West Ham.
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And he did so as an avatar of that other massive trend that has devoured the game over the last decade: velocity. His only blemish that prevented a flawless game was the three walks he issued to go along with seven strikeouts.
"He [Carrick] will start the last match at Old Trafford, the last match of the Premier League", said the United manager during his pre-match press conference.
"The most important quality is to be a man, M-A-N, capitals, a proper man and football is not full of them", said Mourinho.
If Mourinho trusts Carrick's opinion enough to have him play a role in transfer policy then the pair could well form an excellent partnership as the former England global makes his first steps into coaching.
"In this case we decided the bridge could be that bridge, to change shirts and dressing rooms and offices and to stop being a player and become an assistant".
Mourinho hopes midfielder Marouane Fellaini, who has a muscle injury, will be available for the Watford match but he will be absent at West Ham.