City lost at home in the top flight for the first time this season when they were defeated 2-3 in the Manchester derby, a game they should have had wrapped up in the first half.
Guardiola's side should still go on to claim the trophy, and the Catalan coach feels the odd bump along the way only serves to highlight how hard it is to secure domestic dominance.
"In the first-half we tried to do what we've done all season, but maybe it's not enough to win at Champions League level".
A deal for Pogba would have been a huge shock midway through the Premier League season, particularly with the latter having set United back £89million in August 2016, which was then a world record.
"In December, everybody said the EPL is done, but it was a tough fight to keep going every weekend to be focused".
City must overturn a 3-0 first-leg deficit when they host Liverpool for the second leg of their Champions League quarter-final on Tuesday after being hit by a three-goal blitz in 19 first-half minutes at Anfield last week. "It's hard in itself, it's hard for our mood not winning and, yeah, that can happen".
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"We have to win two more games and, after the game on Tuesday, we are going to focus on the EPL to try as quick as possible to get it".
There appeared to be no hangover early on, but the challenge facing Guardiola now is lifting his troops for the return date of a continental clash which has plenty riding on it. We had a good game in general, especially of course the first half.
"Of course we wanted to win today, I'm not going to deny that but we knew exactly we were going to play against, the second in the league".
"Yeah, it can happen", said Guardiola. The schedule is like this, that's why this competition is so tough.
"Until the end we try it and we had the chances and some positions and unfortunately we could not win".
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