Mr Graham predicted "a devastating ripple effect" from Turkish action in Syria, warning that Mr Trump's decision to withdraw the troops opened the way for a Turkish strike on Kurdish-led forces long allied with Washington.
The Kurds were key USA allies in defeating the jihadist group Islamic State (IS) in Syria.
After Turkey's offensive began, there was sign of panic in the streets of Ras al-Ayn- one of the towns under attack with residential areas close to the borders.
At least seven civilians and three members of the Kurdish-led force known as the Syrian Democratic Forces were killed in the Turkish bombardment, Kurdish activists and a Syria war monitor said.
If President Trump follows through on his proposed troop withdrawal from Syria, it would be one of the biggest follies of his presidency and cause ISIS to reemerge in the region, Sen.
"The Turkish Armed Forces, together with the Syrian National Army, just launched Operation Peace Spring", Erdogan tweeted.
Trump later cast his decision to pull back US troops from parts of northeast Syria as fulfilling a campaign promise to withdraw from the "endless war" in the Middle East. The AP could not verify the report independently. Trump has denied he had abandoned the forces, the most capable United States partners in fighting ISIS in Syria.
According to Erdogan, the USA troops that are supporting the Kurdish-led Syrian Democratic Forces have already started pulling out from the region. More than 40 other people had been wounded, according to the Britain-based monitoring group, which has a network of sources across Syria.
Near the Turkish border town of Akcakale, across from Syria's Tel Abyad, a witness saw howitzers placed behind earth embankments on Turkey's side of the border, pointed toward Syria.
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Another member was killed in a drone strike and the fourth is imprisoned on terror charges in Turkey. Attacks had taken place in the immediate vicinity, they said.
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A resident of Tal Abyad said one of the bombs hit an SDF post, and he fled with his wife and mother by auto to Raqqa, almost 100 kilometres (60 miles) to the south, to flee the bombing. The resident, who gave his name as Maher, said the road to Raqqa was packed with vehicles and families, some fleeing on foot "to get away from the bombing". "This left our people defenceless".
But Trump also threatened to "totally destroy and obliterate" Turkey's economy if the Turkish push into Syria went too far. Lindsey Graham, R-S.C., said Wednesday on "Fox & Friends".
The talks made no progress, but such negotiations could be an option again in the event of a wider US withdrawal. (AP) On October 8, Turkish Armed Forces announced that it is ready to combat terror groups including Daesh, PKK and its branches YPG, PYD, SDG. He expected Turkey to protect civilians and religious minorities and to prevent a humanitarian crisis, he said.
Hours after airstrikes in the region, the second phase of Turkey's assault began, as Turkish ground troops crossed the border into northeast Syria, the Turkish Defense Ministry said late Wednesday local time.
Turkey has the largest refugee population in the world, and the presence of Syrians in the country has increasingly led to animosity from Turks who blame them for crime, unemployment and the dilution of Turkish culture.
The Turkish presidency's communications director urged the global community to rally behind Ankara.
Erdogan earlier told Russia's President Vladimir Putin in a phone call that the operation would help peace and stability in Syria.
The SDF halted operations against ISIS because of the Turkish offensive, two U.S. officials and a Kurdish source said.
(Reuters) In this Monday, Oct 7, 2019 photo, Turkish-backed forces from the newly regrouped Syrian National Army exercise during military training in preparation for an anticipated Turkish operation targeting YPG, Syrian affiliation of PKK, near Azaz, in north Syria, before Trump's decision to withdraw the United States forces from Syria.
Kurdish forces have dug trenches and tunnels in both areas, covering streets with metal canopies to block the cameras of Turkish drones.