Epstein hanged himself and his body was found at about 7:30 a.m. on August 10 at Metropolitan Correctional Center in Manhattan.
Epstein, a convicted sex offender who befriended numerous politicians and celebrities over the years, hanged himself in his cell at the Metropolitan Correctional Center, The New York Times and other media said, quoting officials.
Epstein, a wealthy financier who was friends with some of the world's most powerful people, has been accused of exploiting dozens of girls, some of them underage, for sex at his properties in NY and elsewhere.
Prosecutors have accused Epstein of arranging girls under age of 18 to perform nude massages and other sex acts.
Last month, he was placed on a suicide watch after he was found in the fetal position in his jail cell with marks on his neck, according to NBC News.
That investigation, in the U.S. Attorney's office in Manhattan, will continue despite Epstein's death, a source familiar with the matter said.
Last month, Alex Acosta resigned as USA labour secretary over his role in negotiating the plea deal with Epstein. He avoided similar charges in a controversial secret plea deal in 2008, and instead pleaded guilty to a lesser charge.
He faced a maximum sentence of 45 years in prison.
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Magazine profiles followed and established Epstein's reputation as a stealthy yet exorbitantly successful money man with a gilded social circle and as somewhat ascetic streak.
He was often seen socialising with the rich and powerful, including President Donald Trump, former President Bill Clinton and the UK's Prince Andrew. In 2005, the Palm Beach police began investigating him after a parent claimed he molested her 14-year-old daughter. While he was required to register as a sex offender, he was allowed to leave jail six days a week for 12 hours due to a work release provision.
"The alleged behavior shocks the conscience", said U.S. Attorney Geoffrey Berman during a press conference to announce the charges.
April 2017: Alex Acosta is appointed labor secretary by now-President Donald Trump.
"The reckoning of accountability begun by the voices of courageous and truthful victims should not end with Jeffrey Epstein's cowardly and shameful suicide", McCawley said in a statement.
Paramedics tried to revive Epstein as they wheeled him into the hospital but were unsuccessful.
Federal prosecutors in NY reopened the probe after investigative reporting by The Miami Herald stirred outrage over that plea bargain.