However, Sane has not taken being left out of the starting eleven in his stride as the forward has recently revealed that he could possibly return to Germany and join Bundesliga champions Bayern Munich in the summer.
Sane came on as a second-half substitute in a 4-1 win over West Ham on Wednesday in Nanjing and Guardiola is adamant he wants the 23-year-old to stay.
'We want him, we are giving everything, but in the end, if he doesn't want, what can you do? He has a special quality that is hard to find around the world.
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"But, at the same time, I spoke to the club 10 times (to say) I want people here to be happy. The desire to have him to be with us is always there". Then City went through the gears once more of their regular first-teamers were sent on, with Raheem Sterling scoring twice.
"Vincent was an incredibly important player on and off the pitch", said Guardiola, who is struggling badly with jet lag in China following the team's late arrival for the Premier League Asia Trophy. He was a very important player, he made decisions for the team, he played a lot.
De Bruyne and veteran David Silva are believed to be the main contenders to take over and boss Guardiola is happy to let the players make the choice.
"He is our player and we hope that he can stay here this season and next season and next season".