The reds were felled 3-1 in North Carolina previous year, but this time around suffered a slightly improved scoreline of a 3-2 defeat.
The supporters inside the Notre Dame Stadium belted out "You'll Never Walk Alone" in a brilliant rendition of Liverpool's iconic anthem.
Liverpool finished second behind Manchester City in the Premier League last season but went on to win the Champions League by defeating Tottenham Hotspur in the final.
New signing Luuk de Jong could be a threat and he began life at Sevilla with a debut goal in their opening game of their tour of the United States, against FC Dallas on Wednesday.
Without them - and the injured Xherdan Shaqiri - Klopp started last season's cameo hero Divock Origi flanked by Harry Wilson and Ryan Kent, who both shone on loan last season.
Dortmund made their 9 changes at half-time.
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Bruun-Larsen made it 3-1 to Dortmund shortly after and then it was time for Liverpool's extensive substitutions.
Klopp had featured numerous younger players in his starting line-up but handed Trent Alexander-Arnold, Jordan Henderson, Andy Robertson, Virgil van Dijk and Georginio Wijnaldum their first summer match action after making 10 changes on the hour mark.
Other than that, most of the starters will look familiar to anyone who watched Liverpool last season.
A Rhian Brewster penalty in the 75th minute after Ben Woodburn was brought down cut Dortmund's lead to a single goal. He duly dispatched it.
Having faced Borussia Dortmund so soon before kick-off against Sevilla, Klopp will no doubt be managing the minutes of his players with such a congested pre-season schedule.
But he has impressed in pre-season, striking his fourth in three games - a penalty against Dortmund in Friday's U.S. tour fixture - and Sancho says it is a taste of what is to come.