The website DownDetector.com showed a spike in reports of Instagram being unavailable in the afternoon, almost hitting 54,000 before diving back down.
Instagram's official Twitter account wrote: "We're aware that some people are having trouble accessing their Instagram accounts".
There has been no indication as to what caused the outage or when it would be resolved.
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The Uruguay worldwide told Ovacion: "I moved from the Italian championship to a totally different style of football and life". All in all, for me the balance was positive and I am satisfied, satisfied with what I did this season".
Users who tried to access the Facebook-owned photo sharing platform on Friday morning were met with messages which said "server error" or "couldn't refresh feed".
Along with complaints and animated gifs playing on the inconvenience, some offered words of wisdom.
Beginning around 2 p.m. PT on Thursday, Instagram feeds stopped loading and refreshing for some users. "We're working on it and we'll get it fixed as soon as we can". The company acknowledged the snafu and thanked users "for your patience" while it investigated. Down Detector, a website that tracks outages, details reports of issues across the United States, South America, and Europe.
PlayStation did not immediately respond to an AFP request for comment on the outage.