According to the researchers, dementia was diagnosed in 58,769 of the patients.
An editorial accompanying the study noted that despite the proven mechanistic link between anticholinergic drugs and dementia diagnosis, further research was vital to prove causation altogether. The average age of the patients was 82.
The glance interesting inspecting info on 284,343 adults in the United Kingdom, ragged 55 and older, between 2004 and 2016.
The research paper suggested that the risk of dementia is higher in people consuming strongest type of anticholinergic drugs.
Within the 11 years leading up to their dementia diagnosis, 56.6 per cent of the patients (33,253) had been prescribed anticholinergic medications.
Professor Coupland said: "Our study adds further evidence of the potential risks associated with strong anticholinergic drugs, particularly antidepressants, bladder antimuscarinic drugs, anti-Parkinson drugs and epilepsy drugs".
"It also highlights which types of anticholinergic drugs have the strongest associations".
Even earlier, a 2015 study demonstrated an increased risk of dementia and Alzheimer's disease in patients 65 or older who took anticholinergic medications regularly (usually antidepressants, first-generation antihistamines, or bladder control antimuscarinics).Читайте также: Mueller agrees to testify before 2 House panels next month
'From this information we can't rule out whether the diseases that cause dementia might have already begun in the brains of people involved before they started taking these drugs, ' he said.
Scientists had already suspected these drugs might be leading to dementia. The researchers found only an association between anticholinergic drugs and dementia risk, not a causal relationship.
To find out, Coupland's team examined the medical records of almost 59,000 patients in the United Kingdom with dementia, as well as a control group of more than 225,000 patients without dementia.
"This is an observational study so no firm conclusions can be drawn about whether these anticholinergic drugs cause dementia".
The increased risk associated with these drugs indicates that if the association is causal around 10% of dementia diagnoses could be attributable to anticholinergic drug exposure, which would equate to around 20,000 of the 209,600 new cases of dementia per year in the UK.
The risks of anticholinergics "should be carefully considered by healthcare professionals alongside the benefits when the drugs are prescribed and alternative treatments should be considered where possible, such as other types of antidepressants or alternative types of treatment for bladder conditions", Coupland said in a statement.
"I exhaust heaps of my time in the memory disorder hospital seeing geriatric patients and taking folks off medicines, mostly ones which bear anticholinergic properties, and lots of times there'll likely be one other drug on the market that has much less anticholinergic influence or is non-anticholinergic that would possibly move", Scharre stated.
"With little evidence of causation, the next steps for research on anticholinergic medications in older adults must improve knowledge of the effect of deprescribing interventions on cognitive outcomes and important safety outcomes such as symptom control, quality of life, and health care utilization", they wrote.
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