According to The Sun she told the audience, 'be kind or f**k off, ' just before she played the song.
The 33-year-old supermodel reportedly chose to end her relationship with the "A Star is Born" star - with whom she has two-year-old daughter Lea De Seine - at the end of last month because the pair rarely spent any time together.
Their sizzling chemistry and intense gazes sparked speculation that the Star Is Born co-stars were in the midst of a dramatic love affair.
Neither Bradley or Irina have commented on the demise of their relationship, but fans are basically convinced that Lady Gaga was the cause of the schism. "They tried to save the relationship but it had changed".
Indeed, the couple - who are parents to two-year-old daughter Lea De Seine - put on a fearless face when they hit the awards circuit together at the start of the year.
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A source told the newspaper, 'Things are cooling off between Bradley and Irina in a big way.
As she addressed rumours that her friendship with Cooper may have led to the end of her betrothal, Gaga responded: "Yes, people saw love". "Most days, Bradley and Irina take [their two-year-old daughter] Lea out for activities together".
While they had a child and continued living together, the two never got married. "And guess what? That's what we wanted you to see".
"Since Bradley and Irina have always been very private about their relationship, few knew there was really for sure something going on", the source added.
Another shot from Shayk's trip revealed the Russian beauty is no longer wearing her rumored engagement ring from Cooper: a large, floral-inspired emerald sparkler surrounded by a halo of smaller diamonds, which she began sporting around 2016. The rumor mill was put into high gear when Cooper and his longtime girlfriend confirmed that they are parting ways after more than four years.