American President Donald Trump tweeted after the shooting of the unmanned RQ-4A Global Hawk: "Iran made a very big mistake!" "With airlines now suspending and re-routing flights to avoid Iranian airspace, we expect 10-15 per cent hike in fares to Newark-bound flights", ixigo said.
According to flight tracking applications, the FAA said, the nearest civil aircraft was operating within about 45 nautical miles of the unmanned aircraft when it was shot down.
Chicago-based United said in an emailed statement that it had conducted "a thorough safety and security review" of its India service in light of recent events and chose to suspend the route.
"Regardless of any decision they (US. officials) make, we will not allow the Islamic Republic's territory to be violated", Mousavi said.
"All flight operations in the overwater area of the Tehran flight information region (FIR) (OIIX) above the Persian Gulf and Gulf of Oman are prohibited until further notice due to heightened military activities and increased political tensions in the region, which present an inadvertent risk to U.S. Civil Aviation Operations", the FAA said in a notice.
The Netherlands is still reeling from the downing of Malaysia Airlines flight MH17 in 2014, which was hit a missile over eastern Ukraine's Donetsk region where pro-Russian separatist rebels are battling Ukraine government forces.
American Airlines and Delta said they do not fly over Iran.
"The threat of a civil aircraft shootdown in southern Iran is real", it added. United is now the only U.S. airline that flies to India. At 0820 GMT on Friday, Flightradar24 showed Qatar Airways flights in the area barred to United States carriers.
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Iran on Saturday vowed that it would stand firm against any threats to its borders, and issued a warning to the US and its allies in the region, after US President Donald Trump said the military was "cocked and loaded" to strike against Tehran for downing a US drone on Thursday. Qatar Airways did not respond immediately to a request for comment on Friday on whether it had introduced new measures since the drone was shot down.
"Our safety and security team are constantly liaising with authorities - including the likes of the FAA - around the world as part of their comprehensive risk assessment into every route we operate", a BA spokeswoman said.
A United spokesman said customers flying from Mumbai to Newark would be booked on alternative flights back to the United States.
Lufthansa said it would avoid both the Strait of Hormuz and the Gulf of Oman, as well as nearby land. He added that Lufthansa had extended the no-fly zone over Iran on Friday, without being more specific.
"The Europeans will not be given more time beyond July 8 to save the deal", Mousavi said, referring to Iran's deadline of 60 days that Tehran announced in May. Some other worldwide airlines are taking related precautions.
Australia's flag carrier Qantas said: "We're adjusting our flight paths over the Middle East to avoid the Strait of Hormuz and Gulf of Oman until further notice".
Emirates, the long-haul carrier in Dubai near the Strait of Hormuz, told AP it was "rerouting all flights away from areas of possible conflict".
With the United States and Iran training guns on each other, and airlines mulling over whether to avoid Iranian airspace, we are all set to see major bedlam as far as air routes are concerned in the coming days.