But by Monday, a number of tourists were finally able to leave the area, the BBC reported.
The rodent is a known carrier of Yersinia pestis, the bacterium commonly associated with the highly contagious bubonic plague.
Some people ignore the warnings as they believe that consuming the innards of the large rodent is good for their health.
The bubonic plague wiped out millions of people in Eurasia and Europe in the 14th century.
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The 118 people who came in contact with the couple - including seven tourists from Switzerland, Sweden, Kazakhstan and South Korea - were isolated and treated with antibiotics as a precautionary measure, Ochirpurev said.
From 2010 to 2015, there were 3248 cases reported worldwide, including 584 deaths, according to the World Health Organization.
Plague cases are rare in the United States, but incidents do occur in Asia and Africa the CDC reports.
Sebastian Pique, an American Peace Corps volunteer who lives in the region, told AFP: "After the quarantine [was announced], not many people - even locals - were in the streets for fear of catching the disease". The quarantine is expected to be lifted next week.
Pneumonic plague - or lung-based plague - is the most virulent and least common form.
In the middle ages millions of people were killed by the "Black death".