Semedo was substituted at half-time against Eibar as Lionel Messi scored twice in Barcelona's final La Liga game of the season. The brace helped the Argentine legend overtake Cristiano Ronaldo's all-time club record of goals scored.
Two-time UEFA Champions League-winning boss Mourinho was previously of the opinion the Blaugrana skipper should be awarded his sixth Ballon d'Or title, but with the Spanish giants' chances of clinching a treble having since been ended by Liverpool in their elimination from the UCL, the former Chelsea and Inter Milan boss has seemingly made a U-turn on his sentiments.
The five-time Ballon D'Or victor, who scored his 599th and 600th goals for Barcelona against Liverpool in the first leg of the Champions League semi-finals, scored his 601st and 602nd goals on Sunday.
According to Goal.com, no player has ever won the Pichichi by such a clear margin - the previous record of 14 was set in 1986-87 by Hugo Sanchez.
Barcelona added Nelson Semedo to their lengthy list of injury concerns on Sunday, six days before their Copa del Rey final against Valencia.
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His incredible performance in the season makes him one of the favourites to win the Ballon d'Or title this year.
The Catalans captain is battling with Paris Saint Germain youngster Kylian Mbappe, who has 38 goals in all competitions so far.
Barcelona tied Eibar 2-2 as after Messi's goals, Pablo de Blasis scored a fantastic effort to equalize for the home side just before the break.
Messi scored in the 31st and 32nd minute of the Eibar game, after Barcelona conceded an early goal.