According to the Big Cypress National Preserve, researchers collect new data and aim to analyze how the pythons use the nature area.
The team said they caught the snake by tracking a "boyfriend" male snake that had been fitted with a radio transmitter.
Officials say this is the largest python ever removed from Big Cypress National Preserve and was caught using radio transmitters.
"All of the python work at Big Cypress is focused on controlling this invasive species, which poses significant threats to native wildlife", the group said on its Facebook post. Rita Garcia, a spokeswoman for Big Cypress Preserve, said the eggs were destroyed and the snake was euthanized. While studies have shown populations of raccoons have dropped by 99.3 per cent, opossums by 98.9 per cent and bobcats by 87.5 per cent in the areas of the Everglades where pythons have been established longest.
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In this instance, it led the hunters to a record-breaking snake.
Python hunters continue to remove the invasive snakes from South Florida, and they seem to be getting bigger.
In December, a huge 18-foot-long python weighing 150 pounds was caught roaming in the Everglades.
The Florida Fish and Wildlife Commission allows for Burmese pythons to be killed without a permit or hunting license.
The Resource Management staff would like to thank all of the Preseve divisions that have supported the python program.