Flames and smoke are seen billowing from the roof at Notre-Dame Cathedral in Paris on April 15.
The French Gothic cathedral was constructed between 800 and 900 years ago mostly between 1160 and 1260.
The cathedral, which was built in 1160, is engulfed in flames and firefighters are struggling to contain the massive fire.
Details are still emerging but French news agency AFP confirmed that a fire is now underway, citing a Parisian fire service.
It started in the attic of the medieval building around 5.50pm local time and an evacuation took place, local media report.
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The fire department was fighting the flames, while the area near the cathedral was being cleared.
"A awful fire is underway at Notre-Dame Cathedral in Paris", Mayor Anne Hidalgo said on Twitter. "I ask everyone to respect the security perimeter".
French President Emmanuel Macron cancelled a planned address to the nation due to the "terrible fire".
There was no immediate word on the cause of the blaze or of potential victims.
This story is still developing and will be updated.