The tornadoes there struck at about 14:00 (20:00 GMT) on Sunday, carving a path at least a half a mile wide and at least a mile long.
At the Vatican, Pope Francis said he was praying for the dead and injured, saying he is spiritually close to all those who are suffering and grieving.
The twister was part of a powerful storm system that swept through the Deep South, spawning multiple tornado warnings.
Government teams surveying storm damage confirmed that at least 20 tornadoes struck on Sunday in Alabama, Florida, Georgia and SC.
Debris was scattered across the countryside, with shredded metal hanging from the pine trees.
She said David Wayne Dean was at home Sunday afternoon and had texted a friend to beware when the tornado hit.
There are fears that the death toll will rise.
"Just keep those families in your prayers", Lee County Coroner Bill Harris said, two days after the disaster. A post on the Lee-Scott Academy's Facebook page identified fourth-grader Taylor Thornton as being among those killed. "They usually answer on the first ring", she said.
Julie Morrison and her daughter-in-law picked through the ruins of Morrison's home in Beauregard, looking for keys and a wallet. They managed to salvage the couple's safe, her husband's motorcycle boots and her embossed Bible. "That's what we're asking the world to remember her for", her uncle said.
Cindy Sanford, second from right, sifts through the debris with help from her family while retrieving personal items after a tornado destroyed Sanford's home in Beauregard, Ala., March 5, 2019.
Rescue teams in eastern Alabama have resumed search operations a day after two tornadoes caused extensive damage to buildings and roads.
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Fortunately for the residents of Florida, Georgia, and SC, the tornado didn't spill over into any of the three states. Meteorologist Chris Darden said the one that did most of the destruction was a "monster tornado" classified as an EF4.
Alabama search and rescue teams on Tuesday were combing through the wreckage of houses flatted by weekend tornadoes, looking for seven or eight people still unaccounted for in the wake of the deadliest USA twister outbreak since 2013.
'The devastation is incredible, ' said Sheriff Jay Jones.
"The president and I have both spoken to Alabama governor Kay Ivey", Pence said. University of Georgia meteorology professor Marshall Shepherd said government forecasters "were all over it".
The EF-4 tornado left 23 dead, including children, and dozens more missing in the town of Beauregard, making it the deadliest twister in the country since 2013.
John De Block, a meteorologist with the National Weather Service in Birmingham, described the tornado's almost mile-wide path to NPR member station WBHM: "The tornado struck shortly after 2 o'clock in the Macon County/Lee County line".
For Beauregard, the mourning has only just begun.
Officials have not yet released the victim's identities but planned to later Monday evening.
"It's been a tragic situation, but a lot of good work is being done" in the aftermath, Trump said. "No mean bone in her body whatsoever".
Reese told the station in a Monday night interview that 15 of his family members lived on the same street in a lower middle-class area.
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