The absence of both Fernandinho and De Bruyne in midfield could present Phil Foden with a chance to start his first Premier League game of the season.
"Analyse the last one or two months, we are better than [Schalke], but this is one game. It is something unique, the focus is incredible and when you make something wrong they (the opponent) punish it", he added.
Another formation, according to Italian media, would feature Caceres and Cancelo as full backs in a four-man defense with Bonucci and Chiellini in the center.
As with the previous option, that would mean no place for playmaker Paulo Dybala. The last game ended 3-2 in favour Manchester City at the Veltins Arena, Schalke only victory over City came in the semi-finals of the Cup Winners' Cup in 1970.
Manchester City manager Pep Guardiola has provided an injury update on his squad ahead of their fixture with Watford this weekend. "One with nine and we won the first one". Many things can happen in 90 minutes in this kind of competition.
"I would say we are quite lucky that we played 10 v 11 for 23 or 24 minutes 2-1 down".
Over a decade into the club's Abu Dhabi-backed ownership after billions of pounds invested and three domestic titles, conquering Europe remains the mountain City still have to climb.
Max Allegri is considering his future in Turin and many expect him to leave at the end of the season, regardless of his Champions League results or imminent eighth consecutive Scudetto.
Juventus warmed up for their crucial Champions League tie against Atletico Madrid with a straight forward 4-1 win over Udinese on Friday night as youngster Moise Kean starred for the Bianconeri.
Guardiola said: "If people think Real Madrid is out so it will be easy, it's because they still don't understand this competition".
If Guardiola sees out his contract, he would have spent five years in Manchester, compared to four at Barcelona and three at Bayern Munich.
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