Bianca Andreescu from Canada, the current world number 60 who is only 18-years-old, stormed past former world number one Garbiñe Muguruza of Spain 6-0, 6-1. The top half was rocked by the upsets of Djokovic and No. 3 seed Alexander Zverev. "It's small gaps", Nadal said about the upsets.
"If I play Rafa there's extra energy in the building - there's always a lot on the line", he said.
"It will be amusing that somebody other than Novak is still in", Kecmanovic said in reference to top-ranked countryman Djokovic.
Raonic will be Kecmanovic's next opponent after the big-serving 13th seed accounted for German Jan-Lennard Struff 6-4 6-3.
"I enjoy it", Federer said when asked of facing players for the first time.
It marks her eighth win against a top 50 player this year alone.
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On the men's side 20-time Grand Slam champion Roger Federer and his great rival Rafael Nadal both advanced into the quarter finals.
She will now face fifth seed KarolínaPlíšková of the Czech Republic. "Is true that for the last 10 years didn't happen very often". 2 has finally reached the quarter finals of ATP Indian Wells for the first time in three years. But he couldn't overcome Nadal, who lost his serve just once in the 1½-hour match in sunny and windy conditions.
Krajinovic hadn't dropped a set in winning his first three main-draw matches after two wins in qualifying but he was outclassed by Nadal in their one hour and 26 minute encounter.
Nadal commented "I probably played a little bit worse today than yesterday", adding "but in general terms [it's] been a positive victory again".
He will next take on 13th-ranked Russian Karen Khachanov, who beat world No. 9 John Isner 6-4, 7-6 (7/1).
The 13th seed will square off against France's Gael Monfils, a 6-0 6-2 victor over Germany's Philipp Kohlschreiber, in the quarter-finals on Thursday.
Djokovic's loss came on the same day that women's world number one Naomi Osaka saw her title defense hopes dashed, falling 6-3 6-1 to Belinda Bencic.