Ireland's centres and wingers are unchanged from last week's game with France, while Munster duo Niall Scannell and Dave Kilcoyne complete the replacements alongside Leinster's Andrew Porter and Jack Conan.
Twenty seven-year-old Beirne replaces the injured Iain Henderson in Ireland's engine room for the game.
Sean O'Brien returns to the back row in place of Josh van der Flier, who limped off early in the win over Les Bleus. And that's been a really positive challenge for us throughout the Six Nations, and still try to get some cohesion.
"If it was me, I would be concentrating on playing Scotland".
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That's why when I play I try to enjoy the game as much as I can. An all-Spanish affair for the second quarter-final. I'm really very happy for him".
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Armed police were deployed at several locations in all cities, unusual in a country that has had low levels of gun violence. Twitter and Google, which owns YouTube, say they're working to remove any video of the shootings from their sites, as well.
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Vietnamese ambassador to Malaysia, Le Quy Quynh, told AFP at the court: "I'm very disappointed that the court did not free Doan". Officials there did not respond promptly to requests from BenarNews to confirm the information as relayed by her defense team.
"Obviously, he's played plenty of times against the second rows that are going to be there with Adam Beard and Alun Wyn Jones", said Schmidt.
Scrum-half Kieran Marmion may get his first taste of Six Nations action this year off the bench, with Jack Carty and Jordan Larmour covering the rest of the backline. "He knows his Scarlets team-mates very well".
They will hope to crown it by beating Wales to deny them the Grand Slam and keep their hopes of a fourth title since Schmidt took over after the 2013 Six Nations tournament alive - that will depend on whether Scotland beat England at Twickenham.
"With that combination I do think he's as ready as we can get him to be at this stage".
IRELAND: Rob Kearney; Keith Earls, Garry Ringrose, Bundee Aki, Jacob Stockdale; Johnny Sexton, Conor Murray; Cian Healy, Rory Best (capt), Tadhg Furlong; Tadhg Beirne, James Ryan; Peter O'Mahony, Sean O'Brien, CJ Stander.