Ronaldo equalled Messi's Champions League hat-trick record with his eighth in Juventus' 3-0 victory over Atletico on Tuesday - the treble sealing a stunning 3-2 aggregate triumph en route to the quarter-finals.
Messi's Barca could potentially face Ronaldo's Juve in the last eight if the two sides are paired together in Friday's draw for the next round, but the Argentine would not be drawn on who they would prefer to face in the quarterfinals.
Suarez then rounded Lyon goalkeeper Anthony Lopes to lay on a flawless pass for the unmarked Philippe Coutinho to nudge into an open net and double Barca's lead, although Lyon hauled themselves back into contention with a second-half strike from Lucas Tousart. "The important thing is that we got the third goal and then we were far calmer".
Messi opened the scoring with an audacious panenka penalty in the 18th minute, before striking a second time in the 78th minute.
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When he played, and even when he did not, MS Dhoni established how important he is, from behind the stumps and in front of it. They will rejoin their team-mates in mid-May, ahead of World Cup warmup matches against India and West Indies in the UK.
But Messi soon eased their nerves, toying with Lyon's defence before releasing a shot too powerful for Gorgelin to stop.
"In the last few weeks, months even, I've not been playing well", Coutinho told Movistar after helping the Catalan side reach the Champions League quarterfinals for a 12th consecutive season. Home we smash them'.
"We don't want to choose one [side] because they're all really tough", Messi said.
"This just shows you the confidence, the anger, the determination from the best player in the world".
Lyon coach Bruno Genesio added: "Tonight Messi was in Champions League mode".