Below we take a look at how each of the aforementioned quadruple have fared at the quarter-final stage in the Champions League era (1992/93 onwards).
Cristiano Ronaldo's bid to win Juventus their first Champions League since 1996 sees him come up against the conquerors of his old side, Real Madrid.
The two Manchester clubs were also hit by the regulation in 2011-12, when both were drawn at home in the second leg of their round-of-32 Europa League ties.
There will be four Premier League clubs in the pot for the 2018/19 Champions League quarter-final draw for the first time in 10 years after Liverpool joined domestic rivals Man Utd, Man City, and Tottenham in the latter stages of Europe's box office competition.
United great Ryan Giggs believes his former club enter the draw as potential winners after upsetting fancied Paris St Germain to make the quarter-finals.
Ward-Prowse has one senior cap to his name after featuring regularly for the under-21s Credit PA
The two teams have faced each other 11 times in the past, with Barcelona winning four times, United three times and four games ending up in a draw.
"But I would do two matches between English teams, which would mean two teams would be in the semi-finals".
They have also played twice in European knockout stages and, while Porto eliminated the Blaugrana in 1972/73, the 1985/86 tie had the opposite result.
They are doing so, so well during the competition that I think it would be wonderful for one of them.
"I would do Ajax versus Porto, as that would mean one of them reach the semi-finals". Barcelona against Juventus in a possible final or semi-final.
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