Unfortunately for the visitors, Sevilla responded before the half was over through right back Gabriel Mercado, Messi's teammate with Argentina's national squad, who fired the hosts back in front three minutes before the break.
Real Madrid coach Santiago Solari has described Spain's fixture schedule as "curious", with his team's Sunday evening game at Levante giving them a day less than Barcelona to prepare for Wednesday's Copa del Rey semifinal Clasico.
Ousmane Dembele was introduced into the match for Arturo Vidal but the Frenchman should have scored in the 52nd minute when he received a pass from Luiz Suarez which got him wrong-footed. But, it was cancelled out by Lionel Messi's thunderous volley within four minutes to equalize the score.
Messi had two chances within the space of three minute but his shots were tipped over by Sevilla goalkeeper Tomas Vaclik.
What does it mean?
The victory keeps the Catalan giants 10 points ahead of Atletico Madrid and 12 above Real Madrid in the La Liga table.
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In all competitions, he has 33 goals in 32 games - including six in the Champions League as Barcelona chase the treble.
It was the 32nd hat-trick of Messi's La Liga career, while he has notched eight in the Champions League, three in the Copa del Rey, one in the Spanish Super Cup and six in worldwide competition with Argentina.
Elsewhere Getafe beat Rayo Vallecano in a Madrid derby. As those around him failed to fire, he was once again the difference between a draw and a victory.
Lionel MESSI scored hat trick number 50, while reaching 650 goals in his career in FC Barcelona's 4-2 win against Sevilla.
Watch Messi's breathtaking goal here... The only goal came inside the first minute, with Raul Garcia pouncing immediately after the opening whistle.
- Sevilla's Ben Yedder and Sarabia have been involved in 17 La Liga goals this season, more than any other Sevilla player.
Simply put, that's one of his best goals in a while.