The talks are aimed at resolving a trade war that threatens to stunt global economic growth, in part by raising prices on goods for consumers and companies, officials said.
Lighthizer and Mnuchin were seen arriving at a Beijing hotel on Tuesday.
"I think they're making progress and my hope is that by March 1 there will be enough progress to be made that at a minimum, there could be a delay in the imposition of additional tariffs", Portman told reporters.
During an interview Monday, White House Counselor Kellyanne Conway said the president wants to meet with President Xi very soon.
The U.S. president hasn't been clear about whether he'll sit down to finalize a deal with Xi. But the Trump administration seems determined to make such changes happen.
"It will ultimately take".
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Representatives of some 60 nations are set to attend the conference, including the foreign ministers of ten Arab countries. Wednesday's meeting took place at the Warsaw Intercontinental hotel, where Netanyahu's delegation is staying.
Trump said last week he did not plan to meet with Xi before the March 1 deadline.
They are under the gun to seal an accord ahead of the deadline set by Donald Trump, though the U.S. president said yesterday that he was open to extending that, depending on progress in Beijing. "President Trump and President Xi sitting down face-to-face figuring that out and getting that final deal because they are the only two that'll ultimately be able to nail that down", Sanders said. In particular, the U.S.is demanding structural changes to the Chinese economy, including an end to state-subsidies of Chinese-owned businesses and an end to policies that transfer technology intellectual property from US firms to Chinese competitors.
The latest round of talks in Beijing kicked off Monday with discussions among deputy-level officials to try to work out technical details, including a mechanism for enforcing any trade agreement.
China's Foreign Ministry referred questions on the talks to the Ministry of Commerce, which did not respond to a request for comment. USA officials are pressing China to stop allegedly stealing intellectual property from American companies and commit to deeper reforms to a state-driven economic model that they say hurts US competitors.
Two US Navy destroyers conducted a freedom-of-navigation operation in the South China Sea on Monday, challenging China's claims to the Spratly Islands.