The group claimed responsibility for the deadly attack on a luxury hotel complex in Kenya's capital on Tuesday.
The Somali is said to have lost eight soldiers in the battle.
Earlier on Saturday, at least eight Somali soldiers were killed when al-Shabab fighters overran a military camp on the outskirts of the town of Kismayo.
"Alongside our Somali and worldwide partners, we are committed to preventing al-Shabaab from taking advantage of safe havens from which they can build capacity and attack the people of Somalia", the statement said.
The statement says the ambush occurred when the Ethiopian convoy was traveling Burhakaba to Baidoa in Somalia's southwest.
The group could not immediately be reached for comment.
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The air strike targeted al Shabaab fighters who had rammed into the military base near Jilib, 370 km (230 miles) southwest of the capital Mogadishu using a suicide vehicle bomb, military officials in the state of Jubbaland told Reuters. Ethiopia contributes troops to a multinational African Union peacekeeping mission in Somalia and has troops there independently under Ethiopian army command.
The extremist group finds itself under pressure at home on a number of fronts, including from a small presence of rival fighters linked to the Islamic State organization, which has begun challenging al-Shabab in recent months.
"Alongside our Somali and global partners, we are committed to preventing al-Shabaab from taking advantage of safe havens from which they can build capacity and attack the people of Somalia", added the statement from US-Africa command. Some have targeted top leaders or key financial officials.
It is reported that the Al-Shabaab has been using portions of Southern and Central Somalia to plot and direct terror attacks, steal humanitarian aid, extort the local populace to fund its operations, and shelter radical terrorists.
Saturday's strike is the 6th U.S. airstrike in Somalia targeting al-Shabaab in 2019.
The U.S. on Saturday said it is committed to 'preventing al-Shabab from taking advantage of safe havens from which they can build capacity and attack the people of Somalia'.