The world No.29's court coverage was huge as always, regularly chasing down his Italian opponent's forehands and wearing the 34-year-old down over the 2hr 5min clash to make amends for last year's final loss to Daniil Medvedev.
The 19-year-old Australian took the title of the Sydney International.
Sydney-born De Minaur is the first Australian champion at the 134-year tournament since Bernard Tomic in 2013.
Broken in the first game of the opening set, it proved to be one of the few blights on the 19-year-old's game as he broke back five games and barely gave Seppi another look in during the Italian's first final in three-and-a-half years. "To be able to do it at my home in front of my friends and family, it's always that much more special", he said.
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De Minaur has soared 208 places to 29 in the ATP Rankings and was named ATP Newcomer of the Year after earning 28 tour-level victories throughout his 2018 campaign. "So it just took me a while to get used to the rhythm and get back to the play".
The up-and-coming star's straight sets victory is the ideal warm-up two days out from his first-round Australian Open clash with Portugal's Pedro Sousa. "I really appreciate the support", the young Australian said after reaching the Sydney International final for the second straight year, having lost last year's title to Russia's Daniil Medvedev, reports Efe news.
"You know, I'm excited to get out there and try and play my best tennis for myself, my team and the Australian public, but there is certainly no extra pressure from them", Barty said on Saturday.
"But this is what I do the hard work for, to go out there and back it up".
"I came out and absolutely wouldn't be the player I am today if I didn't go". I played three times in the night, so for me it was totally different conditions, which from the beginning I feel very, very slow. "Fitness-wise, I felt like I could keep going, as well".