"I grounded out well and I'm over the moon", said Lowry, who received $1.16 million for his fourth European Tour title but the first in which he led wire-to-wire.
Lowry carded a final-round 71 to reach 18 under par, a shot clear of Richard Sterne, at Abu Dhabi Golf Club.
Lowry responded to a bogey at the next and falling four behind to roll in from eight feet at the par-three 12th and birdie the hole for a fourth consecutive round, before draining a 25-footer at the 13th to cut Sterne's advantage to two.
"To finish with a three is great and, you know, hopefully I can have a little run up the board".
The wire-to-wire victory for Lowry, who tied the course record with a 62 in the first round, will lift him back into the world's top 50 and get him into golf's showpiece events in 2019.
Lowry had an overnight lead of three shots but that was quickly wiped out as the Irishman faltered and Sterne played the first nine holes in 31.
World No. 2 Brooks Koepka (70) finished tied ninth on 277, which meant that England's Justin Rose will remain the world number one irrespective of his finish this week on the US PGA Tour's Desert Classic. I was fearless out there today.
The Queen will be 'absolutely livid — PRINCE PHILIP CRASH
Buckingham Palace said the Queen's husband was uninjured in the crash, which saw his vehicle flipped over onto the driver's side. Mrs Warne's 75-year-old husband, Roy, helped the stricken duke out of his vehicle . "It was turning on its side over and over".
Theresa May 'considers rewriting Northern Ireland's Good Friday agreement'
Theresa May is considering rewriting Northern Ireland's Good Friday agreement to get her Brexit deal passed through Parliament. This motion is expected to attract amendments from groups of backbenchers seeking more of a say in the process.
Leslie Jones slams Jason Reitman’s Ghostbusters sequel
Leslie Jones took to her Twitter to share her very honest thoughts on the new follow-up to the 1984 original. "Like fuck us. Comedian Leslie Jones played Patty Tolan in Feig's reboot and she has been extremely critical of Reitman's upcoming film.
"I've had plenty of conversations with my coach, Neil, in the last few days, about just worrying about what's ahead of me and not worrying about what's going on behind me, when it comes to anything, no matter what score I shoot".
The pressure got to Sterne as he dropped shots at 14 and 16, and a wayward approach to the final green opened the door for Lowry.
"So I've been resting up a lot and hopefully that helps".
After hitting the fairway with his drive, he hit a terrific second shot to the heart of the par 5.
"I'm just glad that I gave a good performance this week with a strong field", he said.
The thrilling ending left Lowry celebrating a first European Tour victory since 2015.