While Oh does not appear to have any past award show hosting credits, Samberg has hosted both the Independent Spirit Awards and the Emmys.
Killing Eve leading lady Sandra Oh and Brooklyn Nine-Nine star Andy Samberg will co-host the 2019 Golden Globe Awards, organisers say.
What do you think of Oh and Sambergas Golden Globes hosts?
The three-hour Golden Globes ceremony will air live on NBC from Beverly Hills.
Oh won a 2006 Golden Globe for "Grey's Anatomy".
"Sandra and Andy are the flawless choices to host this world-class event", Paul Telegdy and George Cheeks, co-chairmen, NBC Entertainment, said in a statement.
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Meher Tatna, president of the Hollywood Foreign Press Association, which hosts the annual Golden Globes show, said he was looking forward to seeing the duo's "undeniable chemistry" onstage.
In an announcement on Wednesday, NBC Entertainment co-chairmen Paul Telegdy and George Cheeks called Oh and Samberg the "perfect choices" for the prestigious event.
The 2018 Golden Globe Awards telecast averaged a 5.0 rating in adults 18-49 and 19 million viewers, according to Nielsen Media Research, putting it ahead of every show on television from the previous 10 months in total viewers, since the prior year's Academy Awards.
Oh received an Emmy nomination for her Killing Eve role (though she did not end up walking away with the trophy), and she's anticipated to also snag a Golden Globe nom for Best Actress in a Television Series Drama this year.
The HFPA changed the title of the honorary position a year ago from Miss Golden Globe to Golden Globe Ambassador, seeking to make the position more gender-neutral. NBC picked it up a few days later.