The Dragon spacecraft, carrying almost 3 tons of science and supplies, is scheduled to rendezvous with the International Space Station on Saturday.
Note, the first stage of the Falcon 9 fell into the Atlantic ocean trying to get back to the launch site in Florida.
SpaceX has launched its unmanned Dragon cargo capsule, propelling its payload to the International Space Station (ISS) despite a post-launch failure affecting the first-stage rocket.
A SpaceX Falcon 9 rocket and Dragon capsule blasted off from Cape Canaveral Air Force Station at 4:10 pm.
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Watch SpaceX's Falcon 9 rocket landing fail in style
For the first time it was used may 11 in mission Bangabandhu, and then August 7 - the mission of Merah Putih . Unfortunately for SpaceX, the launch of the cargo resupply trip wasn't quite ideal .
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But the tall portion of the rocket missed its goal of securing an upright landing on the solid ground at Cape Canaveral's Landing Zone 1. This landing, while not 100% successful, was smooth enough that SpaceX CEO Elon Musk tweeted that the company may re-use the rocket for an internal mission.
The US military described Wednesday's mission as "a successful launch but a non-nominal landing".
According to Musk, the rocket could still be re-used as its engines stabilised the spin just in time to ensure an intact landing in water. 'Ships en route to rescue Falcon'.
Other experiments among the more than 250 on board include a new kind of mustard green lettuce that astronauts will grow in space.
In September 2014, NASA awarded the two companies a huge $6.8 billion contract to ensure that the United States would continue to send USA astronauts to the International Space Station without buying the headquarters of the Russian Soyuz probe.