The family's attorney confirmed he died after being taken to hospital on Monday.
Lee started Marvel Comics in 1961 with The Fantastic Four. The legend, who will be mourned by comic-book lovers and Marvel movie and TV fans, was known as the creator and co-creator of some of Marvel's most beloved characters, including the X-Men, Spider-Man, Iron Man, and Daredevil.
DC Comics, Marvel's competitor, shared a statement regarding Lee's death on Twitter. I think of them as fairy tales for grown-ups.
He hit his stride in the 1960s when he brought the Fantastic Four, the Hulk, Spider-Man, Iron Man and numerous others to life.
As Marvel's Editor-in-Chief, Stan "The Man" Lee made his voice the voice of the stories themselves.
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It's a sad day for Marvel Comic and superhero fans across the globe. In the years between, Lee headed to Los Angeles to help develop Marvel projects for the screen, for which he would serve as executive producer and provide frequent cameos.
Over the course of his career, Lee didn't just write superhero comics, but romance, sci-fi, Westerns and horror - and not just for Marvel.
In the late 1970s and early 1980s, Lee set his sights on Hollywood, and television shows based on Marvel characters began to populate the airwaves.
While giving us such wonderful characters and worlds, Lee was also a big believer in giving back.
The company went bankrupt, and three men were indicted for allegedly defrauding the business in a check kiting scam.
Lee's wife and partner in almost everything, Joan Lee, died on July 6, 2017, leaving a void that made her husband, by then in mental and physical decline, vulnerable to hangers-on who began to surround him.