GWR says work on the line between London Paddington and Ealing Broadway will limit the use of electric trains in this evening's rush hour, causing cancellations and alterations. South Western Railway is accepting GWR tickets on services from London Waterloo to some of the affected stations, while Chiltern Railway will do the same on its services from London Marylebone.
The loss of power stranded many trains between Paddington and Reading.
Network Rail has reopened two of the four lines into the station, meaning a minimal service will be in place for the rest of the day between London Paddington and Reading and Heathrow Airport.
The operator said: Owing to the extent of the damage, no trains are expected to be able to operate between London Paddington and Hayes & Harlington in either direction for much of Wednesday.
Passengers attempting to travel between London and Slough are advised to avoid the station until at least midday.
500m of overhead cables were damaged during a test run of a brand-new Hitachi train on Tuesday night.
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Some services are now running at a major London railway hub after a test train severely damaged overhead electric wires.
"A rail replacement bus service is now operating between London Paddington and Heathrow Airport".
The disruption affected passengers as far as south-west Wales, Bristol, Exeter, Plymouth and Penzance, according to Great Western Railway.
The outage occurred between London and Slough, causing chaos for services connecting the capital to destinations such as Swindon, Reading and Oxford. "No one is held to account for poor service", she said.
"I never take this line and I never will again". Services will depart every 30 minutes.